Project 2: Synthesis of Aerosolized Nano Delivery System
Aerosolization or inhalation of colloidal systems is currently being extensively studied and has huge potential for targeted drug delivery in the treatment of various smoking-related diseases. The fate of inhaled aerosol is dependent on the physicochemical properties of the particle/aerosol and physiological and anatomical features of the respiratory tract. Conventionally, material intended for delivery into the lungs is engineered to be in the 1 to 5 micron size range. Nanostructured particles can influence the depth of penetration, site of deposition and bioavailability in the respiratory tract. In particular, nanomagnetosol (superparamagnetic iron oxide nanoparticles) show potential in magnetic targeting of inhaled aerosols to localized sites within the lung. These particles are also used as contrast agents in magnetic resonance imaging (MRI). Superparamagnetic nanoparticles are highly versatile agents for deep-tissue imaging as well as in-vivo molecular imaging and have thus been incorporated into a variety of nanomedicine platforms. These nanoparticles could also be guided through the body and accumulate at target tissue when exposed to an external magnetic field. Radioisotope labeling and fluorescent labeling may allow for tracing the uptake of the drug into the cell, but the correlation with realistic disease state models is still unknown.
Pulmonary drug delivery is a technology in which drugs are inhaled through the lungs and enter the bloodstream through the alveolar epithelium. The lungs offer a large surface area which, when combined with fine particles/droplets of inhaled aerosol, produces a rapid systemic absorption and quick onset of action. The most challenging part of developing a colloidal system for nebulization is to maintain the critical physicochemical parameters for successful inhalation. Nanoemulsion containing nanomagnetosol functionalized with drugs is capable of retaining its original shape and size when delivered into the lungs. It could be a new alternative for targeted delivery of therapeutics and poorly soluble medicinal compounds via inhalation route. Aerosolized nano delivery system has vast opportunities for the success of nanoparticulate systems.
Prof. Dr Mohd. Basyaruddin Abd. Rahman
|Prof. Noorsaadah Abd. Rahman|
University of Malaya
|Prof. Nagarjun Konduru|
|Prof. AS Md Abdul Haseeb|
University of Malaya
|Assoc. Prof Dr. Wong Tin Wui|