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Project 4

Project 4: Nanofabrication of devices for nanosensing and control of Ganoderma boninense

Malaysia with approximately 50% of palm oil production is counted as the world’s largest producer and exporter of the palm oil. Among various factors, fungal disease by Ganoderma has been the major reason for great losses in palm oil production that lead to potential reduce the market share of palm oil especially for Malaysia with million hectares under oil palm cultivation. Different methods have been used to control Ganoderma infection on existing stands and to reduce incidence in replanting but in advanced infections, none of these methods are entirely satisfactory in reducing the disease effects on the yield. Currently, the most common way for detection of infected trees is visual inspection for Ganoderma specific symptoms that is labor intensive and time consuming. Hence, here We proposed a semiconductor based nanostructure for bio-sensing plat form in Ganoderma boninense pathogen early detection, A standard CMOS process will be employed to define the nanostructure on silicon substrate and subsequently trimmed to desire Nano size. Characterization will be conducted to understand the morphology, optical and electrical behaviour for high selectivity, sensitivity and conductance. Prior to the application of Ganoderma boninense DNA pathogen to the device, its linear response to pH will be confirm by serial dilution from pH 1 to pH14. Then, the sensor surface will be silanized and directly aminated with (3-aminopropyl) triethoxysilane to create a molecular binding chemistry for biofunctionalization. The resulting Si-O-Si- components will be functionalized with receptor Ganoderma boninense ssDNA pathogen, which will interact with the targeted ssDNA to create a field across the silicon nanowire and increase the current. The sensor is expected to shows selectivity for the target ssDNA in a linear range from target ssDNA concentrations. With the envision excellent detection capabilities, this sensor platform is promising for detection of specific biomarkers related Ganoderma boninense DNA pathogen.

 

Uda Bin Hashim
Institute of Nano Electonic Engineering, UniMAP

Objective

  • To prepare and characterize nanostructure for electrical conductivity and selectivity
  • To investigate and evaluate nanostructure surface for ganoderma boninense pathogen probe attachment,
  • To assemble and optimized ganoderma boninense pathogen sensor real clinical sample

Expected Outcome

  • Developing Nano bio-sensor for highly selective and sensitive quantitative measurement in ganoderma boninense pathogen detection

Researchers

  
Ruslinda Binti A. Rahim
Institute of Nano Electonic Engineering, UniMAP
 Dr Mohd Khairuddin Md Arshad
Institute of Nano Electonic Engineering, UniMAP
 Foo Kai Loong
Institute of Nano Electonic Engineering, UniMAP
  
Dr Liu Wei Wen
Institute of Nano Electonic Engineering, UniMAP
 Voon Chun Hong
Institute of Nano Electonic Engineering, UniMAP
 Prof. Dr. Syed M. Usman Ali
Department Electrical and Electronics Engineering, NED University of Engineering & Technology

 

 

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